The Basilica of Santa Rita da Cascia is a minor basilica of Cascia, belonging to the homonymous sanctuary. The mortal remains of Saint Rita are venerated inside.

Rita from Cascia, born Margherita Lotti (Roccaporena, 1381 - Cascia, 22 May 1457), was an Italian nun of the eremitan monastery of Santa Maria Maddalena, beatified by Pope Urban VIII in 1628 and proclaimed Saint by Pope Leo XIII in 1900.)

In the first decades of the twentieth century, the steady increase in pilgrims visiting the reliquary with the remains of Saint Rita made the old church unsuitable for hosting such a large number of people. This was how Mother Maria Teresa Fasce, today blessed, abbess of the nearby monastery of Santa Rita da Cascia where Saint Rita had lived for more than forty years, promoted the construction of a new church suited to the needs of the faithful.